New from SYNkinase for April
Ombrabulin (SYN-3001) A orphan drug
Ombrabulin inhibited tubulin polymerization and inducing mitotic arrest and apoptosis in endothelial cells.
(PAR-1) antagonist, E5555 hydrobromide (SYN-3002) A potent protease-activated receptor
E5555 showed potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC(50) values of 0.064 and 0.031μM, respectively.
GANT61 (SYN-3003) A GLI antagonist
GANT61 is a GLI antagonist that inhibits GLI1 and GLI2-induced transcription with IC50 of 5 μM. It also inhibit the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation.
PF-8380 is a potent inhibitor of autotaxin (IC50 = 2.8 nM in an in vitro enzyme assay). It inhibits autotaxin activity in human whole blood (IC50 = 101 nM).
Our distribution centres in the US, Europe and China will provide you with fast efficient delivery.
Most orders will be delivered the next day depending on the location.